Description
A PDE1 inhibitor (Ki = 0.058 nM); selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM); enhances novel object recognition in rats at 3 and 6 mg/kg; increases prefrontal cortex cAMP and cGMP levels in mice at 50 mg/kg; reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice at 0.1, 3, and 10 mg/kg
Formal name: (6aR,9aS)-2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, monophosphate
Synonyms:
Molecular weight: 605.6
CAS: 1642303-38-5
Purity: ≥98%
Formulation: A solid
