An endogenous AhR agonist; binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays at 0.01 µM; inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells

ITE – 50 mg

Brand:
Cayman
CAS:
448906-42-1
Storage:
-20
UN-No:
Non-Hazardous - /

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist.{52676} It binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays when used at a concentration of 0.01 µM. ITE (1 µM) inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells.{52677,52678} In vivo, ITE (200 µg/animal, i.p.) reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by complete Freund’s adjuvant (CFA) and M. tuberculosis.{52679} ITE (80 mg/kg, i.p.) reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model.{52678}  

 

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SKU: 25355 - 50 mg Category:

Description

An endogenous AhR agonist; binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays at 0.01 µM; inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells at 1 µM; reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by CFA and M. tuberculosis at 200 µg/animal; reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model at 80 mg/kg

Formal name: 2-(1H-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester

Synonyms: 

Molecular weight: 286.3

CAS: 448906-42-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Neuroscience|Ophthalmology

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