An inhibitor of TGF-β (IC50 = 0.85 µM); selective for TGF-β in an SBE4/Smad reporter assay over activin A (83 and 51% inhibition

ITD 1 – 50 mg

Brand:
Cayman
CAS:
1099644-42-4
Storage:
-20
UN-No:
Non-Hazardous - /

ITD 1 is an inhibitor of TGF-β (IC50 = 0.85 µM).{40715} It is selective for TGF-β in an SBE4/Smad reporter assay, providing 83% inhibition when used at a concentration of 2.5 µM, over activin A, which is inhibited by 51% when used at the same concentration. ITD 1 inhibits TGF-β signaling by induction of TGF-β receptor type II degradation. It stimulates differentiation of mouse embryonic stem cells (mESCs) into cardiomyocytes.  

 

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SKU: 23326 - 50 mg Category:

Description

An inhibitor of TGF-β (IC50 = 0.85 µM); selective for TGF-β in an SBE4/Smad reporter assay over activin A (83 and 51% inhibition, respectively at 2.5 µM); stimulates differentiation of mESCs into cardiomyocytes

Formal name: 4-[1,1′-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 415.5

CAS: 1099644-42-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Stem Cell Research|Differentiation

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