Description
An inhibitor of the NF-κB subunit c-Rel; inhibits NF-κB DNA binding (IC50 = 0.1 µM); reduces TNF-α-induced NF-κB activity (IC50 = 4 µM); decreases proliferation of ABC and GCB DLBCLL cells at 3 µM; increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes; increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT; reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma, CLL, and Richter syndrome
Formal name: 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Synonyms:
Molecular weight: 342.4
CAS: 1584121-99-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Stem Cell Research||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
