A small molecule inducer of adult neural stem cell differentiation; 2.5-20 µM triggers neurogenesis and blocks gliogenesis in HCN cells through a neurotransmitter-mediated calcium signal and myocyte-enhancer factor 2-dependent gene expression pathway

ISX-9 – 5 mg

Brand:
Cayman
CAS:
832115-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. At 2.5-20 µM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.{26344,26345,26343} ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.{26343}  

 

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Description

A small molecule inducer of adult neural stem cell differentiation; 2.5-20 µM triggers neurogenesis and blocks gliogenesis in HCN cells through a neurotransmitter-mediated calcium signal and myocyte-enhancer factor 2-dependent gene expression pathway

Formal name: N-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

Synonyms:  Isoxazole 9|Neuronal Differentiation Inducer III

Molecular weight: 234.3

CAS: 832115-62-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience

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