A selective L-type calcium channel blocker with long-acting antihypertensive activity; relaxes depolarization-induced contractions of rabbit aorta (EC50 = 1.4 nM) and reduces the rate of spontaneously beating guinea pig right atria (EC25 = 0.45 nM); attenuates β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease by suppressing calcium influx into the cytoplasm and Cav1.2 expression

Isradipine – 5 mg

Brand:
Cayman
CAS:
75695-93-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.{28540} It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.{28540} By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.{28541}  

 

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Description

A selective L-type calcium channel blocker with long-acting antihypertensive activity; relaxes depolarization-induced contractions of rabbit aorta (EC50 = 1.4 nM) and reduces the rate of spontaneously beating guinea pig right atria (EC25 = 0.45 nM); attenuates β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease by suppressing calcium influx into the cytoplasm and Cav1.2 expression

Formal name: 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-(1-methylethyl) ester

Synonyms:  PN 200-110

Molecular weight: 371.4

CAS: 75695-93-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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