An adrenergic receptor modulator; induces vasodilation of NE-precontracted isolated equine common digital artery strips

Isoxsuprine (hydrochloride) – 5 g

Brand:
Cayman
CAS:
579-56-6
Storage:
-20
UN-No:
- /

Isoxsuprine is an adrenergic receptor modulator that has α-adrenergic receptor (α-AR) antagonist and β-AR agonist properties.{48236,48237} It induces vasodilation of isolated equine common digital artery strips precontracted with norepinephrine, indicating an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol (Item Nos. 23349 | 17291).{48237,32760} Isoxsuprine has antinociceptive effects in an acetic acid writhing test in mice.{32759} It also inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM).{48238} It delays labor onset in rats by 31.63 hours when administered at a dose of 10 mg/kg per day on days 13 to 21 of gestation but increases heart rate with increasing concentration.  

 

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Description

An adrenergic receptor modulator; induces vasodilation of NE-precontracted isolated equine common digital artery strips, an α-AR effect, and induces relaxation of isolated fowl cecum, an effect that can be blocked by the β-AR antagonist propranolol; has antinociceptive effects in an acetic acid writhing test in mice; inhibits oxytocin-induced contractions in isolated rat uterus (IC50 = 9.15 µM); delays labor onset in rats by 31.63 hours at 10 mg/kg on days 13-21 of gestation but increases heart rate with increasing concentration

Formal name: 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-benzenemethanol, monohydrochloride

Synonyms: 

Molecular weight: 337.8

CAS: 579-56-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Neuroscience|Pain Research

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