A C-glycosylated flavone; scavenges DPPH radicals in a cell-free assay (IC50 = 370 µg/ml); cytotoxic to HepG2

Isovitexin – 5 mg

Brand:
Cayman
CAS:
38953-85-4
Storage:
-20
UN-No:
Non-Hazardous - /

Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.{58048,58049,58050,58051,58052} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 370 µg/ml).{58049} Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.{58050} It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.{58051} Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.{58052}  

 

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SKU: 31212 - 5 mg Category:

Description

A C-glycosylated flavone; scavenges DPPH radicals in a cell-free assay (IC50 = 370 µg/ml); cytotoxic to HepG2, MCF-7, and HCT116 cancer cells at 50 and 100 µg/ml; inhibits LPS-induced production of TNF-α and IL-6 and decreases iNOS and COX-2 levels in RAW 264.7 cells at 50 µg/ml; reduces cytotoxicity induced by Aβ (25-35) in PC12 cells at 200 µg/ml

Formal name: 6-β-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 432.4

CAS: 38953-85-4

Purity: ≥98%

Formulation: A crystalline solid

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