A phenylethanoid glycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells at 10 μg/ml; induces apoptosis and production of ROS in

Isoverbascoside – 5 mg

Brand:
Cayman
CAS:
61303-13-7
Storage:
-20
UN-No:
Non-Hazardous - /

Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities.{46570,46571,46572,46573} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml.{46570} Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells.{46571} It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; Item No. 20574).{46572} It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.{46573}  

 

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SKU: 29216 - 5 mg Category:

Description

A phenylethanoid glycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells at 10 μg/ml; induces apoptosis and production of ROS in, and reduces viability of, OVCAR-3 cells from 7.5-30 μM; inhibits tumor growth in an OVCAR-3 mouse xenograft model at 30 mg/kg; decreases brain amyloid deposition and increases exploratory behavior in Aβ42-infused rats at 2.5 and 5 mg/kg; decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock

Formal name: 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside, 6-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms:  Isoacteoside

Molecular weight: 624.6

CAS: 61303-13-7

Purity: ≥95%

Formulation: A crystalline solid

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