A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM

Isovaleryl-L-carnitine (chloride) – 25 mg

Brand:
Cayman
CAS:
139144-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine.{43591} It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM.{43592} Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively.{43593} Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).{32028}  

 

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SKU: 26555 - 25 mg Category:

Description

A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM, respectively

Formal name: (2R)-3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-1-propanaminium, monochloride

Synonyms:  L-Isovalerylcarnitine

Molecular weight: 281.8

CAS: 139144-12-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Carnitines||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Cell Biology|Proteolysis||Research Area|Lipid Biochemistry|Fatty Acids|Degradation

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