Description
A nitric oxide donor with cardioprotective activity; induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively); prevents increases in blood pressure and plasma levels of TXA2, as well as reduces platelet aggregation in a rat model of CSA-induced hypertension when administered prior to CsA at 150 mg/kg; decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis at 200 mg/kg; prolongs survival time of mice in a normobaric hypoxia test
Formal name: 1,4:3,6-dianhydro-D-glucitol 5-nitrate
Synonyms: AHR 4698|BM 22-145|ISMN|Isosorbide 5-mononitrate|Isosorbide 5-nitrate
Molecular weight: 191.1
CAS: 16051-77-7
Purity: ≥95%
Formulation: A crystalline solid
