A nitric oxide donor with cardioprotective activity; induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM

Isosorbide Mononitrate – 1 g

Brand:
Cayman
CAS:
16051-77-7
Storage:
-20
UN-No:
De Minimis - 3251 / 4.1

Isosorbide mononitrate (ISMN) is a nitric oxide (NO) donor with cardioprotective activity.{61008,61009,61010} It induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively).{61008} ISMN (150 mg/kg) prevents increases in blood pressure and plasma levels of thromboxane A2 (TXA2), as well as reduces platelet aggregation in a rat model of hypertension induced by cyclosporin A (CsA; Item No. 12088) when administered prior to CsA.{61009} However, ISMN exacerbates the CsA-induced cardiac phenotype in rats when administered seven weeks after initial CsA administration. ISMN (200 mg/kg) decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis.{61010} It also prolongs survival time of mice in a normobaric hypoxia test.{61011} Formulations containing ISMN have been used in the treatment of angina in patients with coronary artery disease.  

 

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SKU: 31504 - 1 g Category:

Description

A nitric oxide donor with cardioprotective activity; induces relaxation of precontracted isolated rat mesenteric artery rings with and without endothelium (EC50s = 87 and 30.1 µM, respectively); prevents increases in blood pressure and plasma levels of TXA2, as well as reduces platelet aggregation in a rat model of CSA-induced hypertension when administered prior to CsA at 150 mg/kg; decreases aortic superoxide production, reduces intima-media thickness of the thoracic aorta, and improves endothelium-dependent vasorelaxation in a rabbit model of cholesterol-enriched diet-induced atherosclerosis at 200 mg/kg; prolongs survival time of mice in a normobaric hypoxia test

Formal name: 1,4:3,6-dianhydro-D-glucitol 5-nitrate

Synonyms:  AHR 4698|BM 22-145|ISMN|Isosorbide 5-mononitrate|Isosorbide 5-nitrate

Molecular weight: 191.1

CAS: 16051-77-7

Purity: ≥95%

Formulation: A crystalline solid

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