An NO donor; induces vasodilation in isolated precontracted rabbit femoral vein and artery (IC50s = 0.56 and 1.82 µM

Isosorbide Dinitrate – 5 mg

Brand:
Cayman
CAS:
87-33-2
Storage:
-20
UN-No:
Dangerous Good - 2907 / 4.1

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.{36279} It induces vasodilation with IC50 values of 0.56 and 1.82 µM for isolated precontracted rabbit femoral vein and artery, respectively.{36280} Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.{36282} It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.{36281} Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.  

 

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SKU: 23990 - 5 mg Category:

Description

An NO donor; induces vasodilation in isolated precontracted rabbit femoral vein and artery (IC50s = 0.56 and 1.82 µM, respectively); decreases oxygenation of tumor tissue in vivo in mice; inhibits platelet aggregation in vitro and in vivo

Formal name: 1,4:3,6-dianhydro-D-glucitol, 2,5-dinitrate

Synonyms:  NSC 80038

Molecular weight: 236.1

CAS: 87-33-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Vasculature|Vasodilation

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