Description
A flavanolignan with antioxidant and anticancer activities; inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM); inhibits the production of ROS, MDA and LDH release, and reduction in total antioxidant capacity induced by Aβ25-35 in HT-22 hippocampal cells; increases protein and mRNA expression of HO-1, GST, AKCR1C1, and AKCR1C2 in HT-22 cells; reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model at 50 and 100 mg/kg; reduces expression of tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phosphor-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor bearing mice,
Formal name: (2R,3R)-2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Synonyms: Isosilibinin|Isosilybinin|Silybin B
Molecular weight: 482.4
CAS: 72581-71-6
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
