A natural flavonol aglycone that has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM); competitively inhibits MATE1

Isorhamnetin – 10 mg

Brand:
Cayman
CAS:
480-19-3
Storage:
-20
UN-No:
Non-Hazardous - /

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Item No. 10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM).{9540} Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an important role in the excretion of xenobiotics at the kidney and liver.{27212} It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.{27211,27210,27207,27208}  

 

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Description

A natural flavonol aglycone that has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM); competitively inhibits MATE1, Ki = 0.32 µM); potentiates the neurological actions of nerve growth factor, diminishes the cardiotoxic impact of doxorubicin, and can have beneficial anti-cancer effects

Formal name: 3,​5,​7-​​trihydroxy-​2-​​(4-​​hydroxy-​3-​​methoxyphenyl)-​4H-​​1-​​benzopyran-​​4-​one

Synonyms:  3′-O-methyl Quercetin

Molecular weight: 316.3

CAS: 480-19-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Xanthine Oxidase

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