A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis

Isoquercetin – 50 mg

Brand:
Cayman
CAS:
482-35-9
Storage:
-20
UN-No:
Non-Hazardous - /

Isoquercetin is a flavonoid that has been isolated from A. venetum and has diverse biological activities, including antiviral, anti-apoptotic, and neuroprotective properties.{37646,37647,37648} It reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay when used at a concentration of 1 ng/ml.{37646} It inhibits apoptosis, increases cell viability, and decreases the level of reactive oxygen species (ROS) in an oxygen-glucose deprivation/reoxygenation assay when used at concentrations of 25, 50, and 100 µg/ml in primary rat hippocampal neurons and decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM).{37647,37648} Isoquercetin (50 mg/kg) is neuroprotective in a rat model of middle cerebral artery occlusion (MCAO), reducing infarct volume and neurological symptoms, as well as increasing hippocampal expression of Nrf2 and phosphorylation of ERK1/2.{37647}  

 

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SKU: 24926 - 50 mg Category:

Description

A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 µg/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg

Formal name: 2-(3,4-dihydroxyphenyl)-3-(β-D-glucopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one

Synonyms:  NSC 115918|Quercetin 3-O-glucoside|Quercetin 3-β-D-glucoside

Molecular weight: 464.4

CAS: 482-35-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Neuroscience

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