A selective β-adrenoceptor agonist that shows high affinity for β1

Isoproterenol (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
51-30-9
Storage:
-20
UN-No:
Non-Hazardous - /

Isoproterenol is a selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively).{25395,25569} Low concentrations of isoproterenol are sufficient to inhibit contractions in isolated field stimulated rat vas deferens (EC50 = 45.6 nM).{25571} Through its effects on β-adrenoceptor, isoproterenol increases cAMP levels and can activate protein kinase A and ERK1/2.{20876,20862,25568,25569}  

 

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Description

A selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively); inhibits contractions in isolated field stimulated rat vas deferens at low concentrations (EC50 = 45.6 nM); increases cAMP levels and can activate PKA and ERK1/2

Formal name: 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl], monohydrochloride

Synonyms:  Isoprenaline|NSC 37745|NSC 89747

Molecular weight: 247.7

CAS: 51-30-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Vasodilation

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