A bile acid; formed via microbial metabolism of LCA; inhibits TCA-induced spore germination in the C. difficile strains CD196

Isolithocholic Acid – 5 mg

Brand:
Cayman
CAS:
1534-35-6
Storage:
-20
UN-No:
Non-Hazardous - /

Isolithocholic acid is a bile acid that is formed via microbial metabolism of lithocholic acid (LCA; Item No. 20253) or lithocholic acid 3α-sulfate (Item No. 20676).{54013,43814} Isolithocholic acid (0.01%) inhibits spore germination induced by taurocholic acid (TCA; Item No. 16215) in the C. difficile strains CD196, M68, BI9, and 630, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.0003%.{54006} Fecal levels of isolithocholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}  

 

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Description

A bile acid; formed via microbial metabolism of LCA; inhibits TCA-induced spore germination in the C. difficile strains CD196, M68, BI9, and 630 at 0.01%, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells at 0.0003%; fecal levels are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet

Formal name: (3β,5β)-3-hydroxy-cholan-24-oic acid

Synonyms:  isoLCA|isolithocholate

Molecular weight: 376.6

CAS: 1534-35-6

Purity: ≥95%

Formulation: A solid

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