A flavonoid with diverse biological activities; inhibits LPS-induced nitrite and PGE2 production in RAW 264.7 cells at 1.6 µM; inhibits tube formation by isolated rat aortic endothelial cells from 5-500 µg/ml; reduces carmine content and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg

Isoliquiritin – 5 mg

Brand:
Cayman
CAS:
5041-81-6
Storage:
-20
UN-No:
Non-Hazardous - /

Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.{54056,54057,54058} It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM.{54056} Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.{54057} In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.{54058}  

 

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SKU: 30270 - 5 mg Category:

Description

A flavonoid with diverse biological activities; inhibits LPS-induced nitrite and PGE2 production in RAW 264.7 cells at 1.6 µM; inhibits tube formation by isolated rat aortic endothelial cells from 5-500 µg/ml; reduces carmine content and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively); increases cortical, hippocampal, and hypothalamic 5-HT and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice from 10-40 mg/kg

Formal name: (2E)-1-(2,4-dihydroxyphenyl)-3-[4-(β-D-glucopyranosyloxy)phenyl]-2-propen-1-one

Synonyms:  Isoliquiritoside

Molecular weight: 418.4

CAS: 5041-81-6

Purity: ≥98%

Formulation: A crystalline solid

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