A natural furanocoumarin that inhibits CYP1A activity

Isoimperatorin – 10 mg

Brand:
Cayman
CAS:
482-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.{32150,32151} Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.{32151,32152} Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.{32152}  

 

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Description

A natural furanocoumarin that inhibits CYP1A activity, in particular blocking hepatic EROD activity; also induces the expression of GSTα by activating Nrf2

Formal name: 4-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms: 

Molecular weight: 270.3

CAS: 482-45-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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