A biflavonoid inhibitor of pre-mRNA splicing; reduces the activity of an mRNA-dependent luciferase reporter

Isoginkgetin – 1 mg

Brand:
Cayman
CAS:
548-19-6
Storage:
-20
UN-No:
Non-Hazardous - /

Isoginkgetin is a biflavonoid that has been found in G. biloba and is an inhibitor of pre-mRNA splicing.{37675} Isoginkgetin (33 μM) reduces the activity of an mRNA-dependent luciferase reporter by 5-fold, shifts the composition of total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells. Isoginkgetin (10 μM) suppresses mouse lymphocyte proliferation induced by concanavalin A (Con A; Item No. 14951) and LPS by approximately 87 and 90%, respectively.{37676} It also suppresses arachidonic acid release induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) by 32.5 and 48.4%, respectively, in rat peritoneal macrophages when used at a concentration of 10 μM.{37677} Isoginkgetin (5-20 μM) reduces matrix metalloproteinase-9 (MMP-9) activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells in a concentration-dependent manner.{37678}  

 

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SKU: 25104 - 1 mg Category:

Description

A biflavonoid inhibitor of pre-mRNA splicing; reduces the activity of an mRNA-dependent luciferase reporter, shifts the total RNA extract from predominantly mRNA to pre-mRNA, and arrests cell growth in HEK293 cells at 33 μM; suppresses Con A- and LPS-induced mouse lymphocyte proliferation at 10 μM; suppresses PMA- and A23187-induced arachidonic acid release in rat peritoneal macrophages at 10 μM; dose-dependently reduces MMP-9 activity, expression, and mRNA levels in and decreases cell invasion by HT1080 fibrosarcoma cells from 5-20 μM

Formal name: 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 566.5

CAS: 548-19-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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