A diterpene with diverse biological activites; demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 μM); decreases systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day

Isoforskolin – 1 mg

Brand:
Cayman
CAS:
64657-21-2
Storage:
-20
UN-No:
Non-Hazardous - /

Isoforskolin is a naturally occurring diterpene originally isolated from the Indian coleus plant C. forskohlii.{41420} It demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 μM).{41421} In vivo, isoforskolin is antihypertensive, decreasing systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days. Pretreatment of rats with isoforskolin (10 mg/kg, i.p.) decreases LPS-induced lung injury by decreasing karyocyte, neutrophil count, and protein content in bronchoalveolar lavage fluid, and ameliorating LPS-induced lung morphological changes.{41423} Isoforskolin (1 mg/kg, i.p.) decreases mean arthritis index in a mouse model of Lyme arthritis induced by injection of B. burgdorferi basic membrane protein A (BmpA) into the tibiotarsal joint cavity.{41424} Isoforskolin also activates membranous mammalian adenylyl cyclase (AC) expressed in insect cells (EC50s = 0.8, 13.3, and 7.4 μM for AC1, AC2, and AC5, respectively).{41422}  

 

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SKU: 11716 - 1 mg Category:

Description

A diterpene with diverse biological activites; demonstrates positive inotropic effects ex vivo in guinea pig atria (EC50 = 1.09 μM); decreases systolic blood pressure by 28 mmHg in spontaneously hypertensive rats when administered at 25 mg/kg per day, p.o. for 5 days; decreases LPS-induced lung injury in pretreated rats (10 mg/kg, i.p.); decreases mean arthritis index in a mouse model of Lyme arthritis (1 mg/kg, i.p.); activates membranous mammalian AC1, AC2, and AC5 expressed in insect cells (EC50s = 0.8, 13.3, and 7.4 μM, respectively)

Formal name: (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one

Synonyms: 

Molecular weight: 410.5

CAS: 64657-21-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Activators|Cyclases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Innate Immunity

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