A halogenated ether with anesthetic properties; isoflurane-resistant mice have an 86% decrease in GABAA receptor subunit β1 gene expression compared with isoflurane-sensitive mice; impairs spatial recognition memory and increases phosphorylated Jnk1/2 in mice for at least 24 hours

Isoflurane – 1 g

Brand:
Cayman
CAS:
26675-46-7
Storage:
-20
UN-No:
De Minimis - 3334 / 9

Isoflurane is a halogenated ether with anesthetic properties.{37284} While the mechanism of isoflurane anesthesia is not fully understood, mice resistant to isoflurane anesthesia have an 86% decrease in gene expression for the GABAA receptor subunit β1 compared with isoflurane-sensitive mice, indicating that the GABAA receptor may be required for its anesthetic effect. In mice, isoflurane (1.5% for 4 hours) impairs spatial recognition memory in the spontaneous alternation test and Y-maze and increases levels of phosphorylated Jnk1/2 for at least 24 hours.{37283} Formulations containing isoflurane have been used as anesthetics.  

 

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Description

A halogenated ether with anesthetic properties; isoflurane-resistant mice have an 86% decrease in GABAA receptor subunit β1 gene expression compared with isoflurane-sensitive mice; impairs spatial recognition memory and increases phosphorylated Jnk1/2 in mice for at least 24 hours

Formal name: 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane

Synonyms:  (±)-Isoflurane

Molecular weight: 184.5

CAS: 26675-46-7

Purity: ≥98%

Formulation: A neat oil

Product Type|Biochemicals|Ion Channel Modulation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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