A bile acid; formed via epimerization of DCA by intestinal bacteria; has a greater critical micelle concentration than DCA; less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species; inhibits spore germination induced by taurocholic acid in several C. difficile strains

Isodeoxycholic Acid – 5 mg

Brand:
Cayman
CAS:
566-17-6
Storage:
-20
UN-No:
Non-Hazardous - /

Isodeoxycholic acid is a bile acid that is formed via epimerization of deoxycholic acid (DCA; Item Nos. 20756 | 18231) by intestinal bacteria.{54005} It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species. Isodeoxycholic acid (0.1%) inhibits spore germination induced by taurocholic acid (Item No. 16215) in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells.{54006} Plasma levels of isodeoxycholic acid are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.{54007}  

 

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SKU: 29890 - 5 mg Category:

Description

A bile acid; formed via epimerization of DCA by intestinal bacteria; has a greater critical micelle concentration than DCA; less active than DCA in inhibiting growth in a panel of seven gut commensal bacteria species; inhibits spore germination induced by taurocholic acid in several C. difficile strains, as well as decreases the cytotoxicity of C. difficile culture supernatants to Vero cells, at 0.1%; plasma levels are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet

Formal name: (5β,7α,12α)-7,12-dihydroxy-cholan-24-oic acid

Synonyms:  isoDCA

Molecular weight: 392.6

CAS: 566-17-6

Purity: ≥95%

Formulation: A solid

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