An aporphine alkaloid; reduces the action potential duration and amplitude in isolated canine Purkinje fibers at 100 µM; induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips (EC50 = 12.6 µM); cytotoxic to A549 lung cancer cells (IC50 = 197.73 µM)

Isocorydine – 25 mg

Brand:
Cayman
CAS:
475-67-2
Storage:
-20
UN-No:
Non-Hazardous - /

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.{52447,52448,52449,52450,52451} It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 µM.{52448} Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 µM.{52449} It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively).{52450,52451} Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.{52451}  

 

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SKU: 30101 - 25 mg Category:

Description

An aporphine alkaloid; reduces the action potential duration and amplitude in isolated canine Purkinje fibers at 100 µM; induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips (EC50 = 12.6 µM); cytotoxic to A549 lung cancer cells (IC50 = 197.73 µM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 µg/ml, respectively); reduces tumor growth in a Huh7 mouse xenograft model when used in combination with doxorubicin

Formal name: (6aS)-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol

Synonyms:  NSC 32979

Molecular weight: 341.4

CAS: 475-67-2

Purity: ≥98%

Formulation: A crystalline solid

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