An inhibitor of MAO (IC50 = 4.8 μM for rat brain MAO); induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM; potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine; inhibits 90% of MAO activity in isolated rat hearts and reduces isoproterenol-induced cardiomegaly in rats; increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC

Isocarboxazid – 10 mg

Brand:
Cayman
CAS:
59-63-2
Storage:
-20
UN-No:
De Minimis - 3249 / 6.1

Isocarboxazid is an inhibitor of monoamine oxidase (MAO; IC50 = 4.8 μM for rat brain MAO).{38384} It induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM. In vivo, isocarboxazid potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine). It inhibits 90% of MAO activity in isolated rat hearts and reduces cardiomegaly induced by isoproterenol (Item No. 15592) in rats at a dose of 20 mg/kg.{38385} Oral administration of isocarboxazid (10 mg/kg) increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, homovanillic acid (HVA; Item No. 20877), and 5-hydroxy indole-3-acetic acid (5-HIAA; Item No. 22889) by 43, 32, and 28%, respectively, in mouse brain.{38386} Formulations containing isocarboxazid have been used for the treatment of minor depression.{38387}  

 

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SKU: 23625 - 10 mg Category:

Description

An inhibitor of MAO (IC50 = 4.8 μM for rat brain MAO); induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM; potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine; inhibits 90% of MAO activity in isolated rat hearts and reduces isoproterenol-induced cardiomegaly in rats; increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, HVA, and 5-HIAA in mouse brain,

Formal name: 5-methyl-3-isoxazolecarboxylic acid, 2-(phenylmethyl)hydrazide

Synonyms:  NSC 169893|Ro 5-0831

Molecular weight: 231.3

CAS: 59-63-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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