A monoterpene alcohol; reduces 6-OHDA-induced cell death in SH-SY5Y cells via inhibition of apoptosis

Isoborneol – 25 g

Brand:
Cayman
CAS:
124-76-5
Storage:
-20
UN-No:
Excepted Quantity - 1325 / 4.1

Isoborneol is a monoterpene alcohol that has been found in a variety of plants, including C. sativa, C. indica, and C. sativa/C. indica hybrid strains, with neuroprotective and antiviral activities.{42303,42450,42451} It reduces SH-SY5Y cell death induced by 6-OHDA (Item No. 25330) when used at concentrations ranging from 2.5 to 10 μM via inhibition of apoptosis, reducing increases in intracellular levels of reactive oxygen species (ROS), and preventing decreases in the mitochondrial membrane potential.{42450} Isoborneol (0.03 and 0.06%) reduces HSV-1 viral replication by inhibiting viral protein synthesis.{42451} It inhibits the glycosylation of HSV-1 glycoprotein gB but has no effect on protein glycosylation in Vero cells.  

 

Available on backorder

Add to quotes
SKU: 23177 - 25 g Category:

Description

A monoterpene alcohol; reduces 6-OHDA-induced cell death in SH-SY5Y cells via inhibition of apoptosis, reducing increases in intracellular levels of ROS, and preventing decreases in the mitochondrial membrane potential from 2.5-10 μM; reduces HSV-1 viral replication by inhibiting viral protein synthesis at 0.03 and 0.06%; inhibits the glycosylation of HSV-1 glycoprotein gB ,

Formal name: (1R,2R,4R)-rel-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Synonyms:  (±)-Isoborneol|DL-Isoborneol|Isobornyl Alcohol|NSC 26350

Molecular weight: 154.3

CAS: 124-76-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV||Research Area|Neuroscience|Cannabinoid Research

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 50 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 250 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 250 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page