An internal standard for the quantification of irinotecan by GC- or LC-MS

Irinotecan-d10 (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
718612-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

Irinotecan-d10 is intended for use as an internal standard for the quantification of irinotecan (Item No. 14180) by GC- or LC-MS. Irinotecan, a derivative of the alkaloid camptothecin (Item No. 11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I.{21114, 21115} Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1.{22661, 22662} Formulations containing irinotecan demonstrate broad spectrum antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors and have proven useful in radiation treatment of tumors by sensitizing tissue to radiation damage.{21114, 21115}  

 

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Description

An internal standard for the quantification of irinotecan by GC- or LC-MS

Formal name: (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl [1,4′-bipiperidine]-1′-carboxylate-2,2,3,3,4,4,5,5,6,6-d10, monohydrochloride

Synonyms:  Camptothecin 11-d10|CPT 11- d10|Topotecin-d10|U 101440E-d10

Molecular weight: 633.2

CAS: 718612-62-5

Purity: ≥95% deuterated forms (d1-d10)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Migration & Metastasis

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