A cell-permeable compound that maintains long-term mouse ESC pluripotency; allows ESCs to form embryoid bodies that continue to express markers of pluripotency when used at 4 µg/ml with Wnt3a; blocks the interaction of Nkd with a subunit of PP2A

IQ-1 – 50 mg

Brand:
Cayman
CAS:
331001-62-8
Storage:
-20
UN-No:
Non-Hazardous - /

IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that maintains long-term mouse embryonic stem cell (ESC) pluripotency.{26541} When used at 4 µg/ml with Wnt3a, it allows ESCs to form embryoid bodies that continue to express markers of pluripotency, including α-fetoprotein and β-III tubulin.{26541} IQ-1 blocks the interaction of the protein Naked cuticle with a subunit of the protein phosphatase PP2A, altering signaling through Wnt/β-catenin and maintaining the expression of stem cell markers Oct4, Nanog, and Rex1 in ESCs.{26541}  

 

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Description

A cell-permeable compound that maintains long-term mouse ESC pluripotency; allows ESCs to form embryoid bodies that continue to express markers of pluripotency when used at 4 µg/ml with Wnt3a; blocks the interaction of Nkd with a subunit of PP2A

Formal name: 2-[2-(4-acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide

Synonyms: 

Molecular weight: 362.4

CAS: 331001-62-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Stem Cell Research||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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