A potent

IPI-145 – 10 mg

Brand:
Cayman
CAS:
1201438-56-3
Storage:
-20
UN-No:
Non-Hazardous - /

IPI-145 is a potent inhibitor of the phosphoinositide 3-kinase (PI3K) isoforms PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively).{27763} It is orally bioavailable and selective.{27763} As PI3Kγ and PI3Kδ are preferentially expressed in immune cells, IPI-145 has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models.{27763,27764} It also has potential applications in immunotherapy and in certain cancers.{27762,27761}  

 

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Description

A potent, selective, and orally bioavailable inhibitor of PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively); has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models

Formal name: 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1(2H)-isoquinolinone

Synonyms:  Duvelisib|INK1197

Molecular weight: 416.9

CAS: 1201438-56-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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