An agonist of muscarinic acetylcholine receptors; stimulates [35S]GTPγS binding CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM

Iperoxo (iodide) – 1 mg

Brand:
Cayman
CAS:
247079-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

Iperoxo is an agonist of muscarinic acetylcholine receptors.{48128,42728} It stimulates [35S]GTPγS binding to CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM, respectively).{48128} Iperoxo induces M1-dependent inhibition of the twitch response in electrically-stimulated isolated rabbit vas deferens (pD2 = 9.87) and M3-mediated contraction of isolated guinea pig ileum (pD2 = 9.78).{42728} In vivo, iperoxo reduces formalin-induced paw licking and acetic acid-induced writhing in mice (ED50s = 0.004 and 0.001 mg/kg, respectively).{42729}  

 

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SKU: 27235 - 1 mg Category:

Description

An agonist of muscarinic acetylcholine receptors; stimulates [35S]GTPγS binding CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM, respectively); induces M1-dependent inhibition of twitch response in electrically-stimulated isolated rabbit vas deferens (pD2 = 9.87) and M3-mediated contraction of isolated guinea pig ileum (pD2 = 9.78); reduces formalin-induced paw licking and acetic acid-induced writhing in mice (ED50s = 0.004 and 0.001 mg/kg, respectively),

Formal name: 4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monoiodide

Synonyms: 

Molecular weight: 324.2

CAS: 247079-84-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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