A modulator of CFTR; inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM); has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM

IOWH-032 – 10 mg

Brand:
Cayman
CAS:
1191252-49-9
Storage:
-20
UN-No:
Non-Hazardous - /

IOWH-032 is a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).{58097,58098} It inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM).{58097} It has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM, respectively.{58098} IOWH-032 (20 nM) also potentiates currents through CFTR bearing the F508 deletion mutation (ΔF508-CFTR) expressed in X. laevis oocytes. It inhibits, but does not potentiate, mouse CFTR with an apparent Kd value of 42.9 µM.  

 

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SKU: 30273 - 10 mg Category:

Description

A modulator of CFTR; inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM); has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM, respectively; potentiates currents through ΔF508-CFTR expressed in X. laevis oocytes at 20 nM; inhibits mouse CFTR with an apparent Kd value of 42.9 µM

Formal name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide

Synonyms: 

Molecular weight: 545.2

CAS: 1191252-49-9

Purity: ≥98%

Formulation: A crystalline solid

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