A diterpenoid related to phorbol that activates PKC (Ki = 30 μM; ED50 = 27 μM) and promotes tumor formation

Ingenol – 5 mg

Brand:
Cayman
CAS:
30220-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus.{771} It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro.{23438,23437} Most ingenol esters are tumor-promoting.{17808} However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.{21836}  

 

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Description

A diterpenoid related to phorbol that activates PKC (Ki = 30 μM; ED50 = 27 μM) and promotes tumor formation

Formal name: (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one

Synonyms: 

Molecular weight: 348.4

CAS: 30220-46-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|PKC Signaling

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