A plant metabolite with plant fungal resistance

Indole-3-carboxylic Acid – 100 g

Brand:
Cayman
CAS:
771-50-6
Storage:
-20
UN-No:
Non-Hazardous - /

Indole-3-carboxylic acid is a plant metabolite derived from tryptophan that has been found in Arabidopsis and has diverse biological activities.{57276,57277,57278,57279} It induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina when applied as a soil-drenching solution at a concentration of 150 µM prior to infection.{57277} Indole-3-carboxylic acid is cytotoxic to A549 human lung and MCF-7 human breast cancer cells (EC50s = 4.6 and 12.9 µg/ml, respectively) and inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 µg/ml).{57278} Indole-3-carboxylic acid has also been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity.{57279}  

 

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SKU: 31166 - 100 g Category:

Description

A plant metabolite with plant fungal resistance, HIV inhibitory, and anticancer activities; induces resistance in Arabidopsis against the plant necrotrophic fungus P. cucumerina as a 150 µM soil-drenching solution; cytotoxic to A549 and MCF-7 cancer cells (EC50s = 4.6 and 12.9 µg/ml, respectively); inhibits HIV replication in infected H9 lymphocytes (IC50 = 16.4 µg/ml); has been used as a precursor in the synthesis of substituted thiadiazoles with anticancer activity

Formal name: 1H-indole-3-carboxylic acid

Synonyms:  I3CA|ICOOH|Indole-β-carboxylic Acid|β-Indolylcarboxylic Acid

Molecular weight: 161.2

CAS: 771-50-6

Purity: ≥98%

Formulation: A crystalline solid

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