A sulfonamide with anticancer activity (IC50s = 0.11 and 94 μg/ml

Indisulam – 1 mg

Brand:
Cayman
CAS:
165668-41-7
Storage:
-20
UN-No:
Non-Hazardous - /

Indisulam is a sulfonamide with anticancer activity.{38165} In vitro, indisulam has antiproliferative effects on a wide range of human tumor lines with HCT116 colorectal being the most sensitive and NCI-H596 non-small cell lung cancer (NSCLC) the most resistant (IC50s = 0.11 and 94 μg/ml, respectively). It increases the number of P388 murine leukemia cells in the G1 phase of the cell cycle in a dose-dependent manner and exerts time-dependent cytotoxicity against HCT116 cells. In vivo, indisulam suppresses tumor growth and decreases tumor volume in murine HCT116, SW620, and HCT15 colorectal and LX-1 and PC9 lung cancer xenograft models. Indisulam induces proteasomal degradation of RNA binding motif protein 39 (RBM39) through association with the CUL4-DCAF15 E3 ubiquitin ligase in vitro.{38166} It is also an inhibitor of carbonic anhydrase in H. pylori (Ki = 310-562 nM).{33180} Formulations containing indisulam are under clinical investigation for the treatment of solid tumors.{38167}  

 

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Description

A sulfonamide with anticancer activity (IC50s = 0.11 and 94 μg/ml, for HCT116 and NCI-H596 cells, respectively); increases the number of P388 murine leukemia cells in the G1 phase of the cell cycle in a dose-dependent manner; exerts time-dependent cytotoxicity against HCT116 cells; suppresses tumor growth and decreases tumor volume in murine HCT116, SW620, and HCT15 colorectal and LX-1 and PC9 lung cancer xenograft models; induces proteasomal degradation of RBM39 through association with the CUL4-DCAF15 E3 ubiquitin ligase in vitro; an inhibitor of carbonic anhydrase in H. pylori (Ki = 310-562 nM),

Formal name: N1-(3-chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

Synonyms:  E-7070

Molecular weight: 385.8

CAS: 165668-41-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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