An inhibitor of HGFR potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM); orally bioavailable

INCB 28060 – 50 mg

Brand:
Cayman
CAS:
1029712-80-8
Storage:
-20
UN-No:
Non-Hazardous - /

INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).{32148} It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells.{32148} INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice.{32148} It also improves efficacy of gemcitabine (Item No. 11690) in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.{32147,32149}  

 

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Description

An inhibitor of HGFR potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM); orally bioavailable, inhibiting the growth of HGFR-dependent tumors in mice

Formal name: 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-benzamide

Synonyms:  Capmatinib|INC 280

Molecular weight: 412.4

CAS: 1029712-80-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules

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