Description
An anti-choroidal neovascularization agent; inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines (IC50s = 0.3-3 µM); decreases migration of THP-1 macrophages in wound healing and chamber assays at 10 µM; inhibits VEGF-induced blood vessel formation in a MatrigelTM plug assay in mice at 20 µg/animal; reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization at 100 µg/eye
Formal name: (3E)-2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one
Synonyms:
Molecular weight: 296.3
CAS: 1031206-36-6
Purity: ≥98%
Formulation: A solid
