An inhibitor of importin-β-mediated nuclear import (IC50 = 15 μM in HEK293 cells); does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export

Importazole – 50 mg

Brand:
Cayman
CAS:
662163-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus.{34596} Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout.{34596} Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export.{34596} Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells.{34598,34600} It also induces defects in spindle and microtubule formation in vitro.{34597}  

 

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Description

An inhibitor of importin-β-mediated nuclear import (IC50 = 15 μM in HEK293 cells); does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export

Formal name: N-(1-phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine

Synonyms:  IPZ

Molecular weight: 318.4

CAS: 662163-81-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Immunology & Inflammation|Adaptive Immunity

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