A furanocoumarin with diverse biological activities; decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in R-HepG2 cells

Imperatorin – 50 mg

Brand:
Cayman
CAS:
482-44-0
Storage:
-20
UN-No:
Non-Hazardous - /

Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities, including anticancer, anti-inflammatory, and antioxidant properties.{47081,47082,47083} It decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in doxorubicin-resistant HepG2 (R-HepG2) cells, an effect that can be reversed by overexpression of MCL-1.{47081} Imperatorin inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells in vitro (IC50s = 28.1 and 43.3 μM, respectively) and reduces tumor growth in an R-HepG2 mouse xenograft model when administered at a dose of 50 mg/kg. Imperatorin inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages.{47082} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals (EC50s = 19.48 and 10.93 μM, respectively).{47083} Imperatorin also has antibacterial, antiviral, and anticonvulsant activities.{47081,47082}  

 

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SKU: 26070 - 50 mg Category:

Description

A furanocoumarin with diverse biological activities; decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in R-HepG2 cells, an effect that can be reversed by overexpression of MCL-1; inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells (IC50s = 28.1 and 43.3 μM, respectively); reduces tumor growth in an R-HepG2 mouse xenograft model at 50 mg/kg; inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages; scavenges DPPH and ABTS radicals (EC50s = 19.48 and 10.93 μM, respectively); has antibacterial, antiviral, and anticonvulsant activities

Formal name: 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  Marmelosin|NSC 402949

Molecular weight: 270.3

CAS: 482-44-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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