A potent histamine H3 receptor agonist (Ki = 0.85 nM); selective for histamine H3 over histamine H4 receptors (Ki = 245 nM); inhibits cAMP-stimulated β-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM); induces a decrease of the electrically induced twitch contraction in isolated guinea pig ileum; inhibits hydrochloric acid-induced formation of gastric lesions in rats at 30 mg/kg

Immethridine (hydrobromide) – 5 mg

Brand:
Cayman
CAS:
699020-93-4
Storage:
-20
UN-No:
Non-Hazardous - /

Immethridine is a potent histamine H3 receptor agonist (Ki = 0.85 nM).{46585} It is selective for histamine H3 over histamine H4 receptors (Ki = 245 nM). Immethridine inhibits cAMP-stimulated β-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM) and induces a concentration-dependent decrease of the electrically induced twitch contraction in isolated guinea pig ileum. In vivo, immethridine (30 mg/kg, s.c.) inhibits hydrochloric acid-induced formation of gastric lesions in rats.{46586}  

 

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SKU: 29502 - 5 mg Category:

Description

A potent histamine H3 receptor agonist (Ki = 0.85 nM); selective for histamine H3 over histamine H4 receptors (Ki = 245 nM); inhibits cAMP-stimulated β-galactosidase transcription in SK-N-MC cells expressing human H3 receptors (EC50 = 0.18 nM); induces a decrease of the electrically induced twitch contraction in isolated guinea pig ileum; inhibits hydrochloric acid-induced formation of gastric lesions in rats at 30 mg/kg, s.c.

Formal name: 4-(1H-imidazol-5-ylmethyl)-pyridine, dihydrobromide

Synonyms: 

Molecular weight: 321

CAS: 699020-93-4

Purity: ≥98%

Formulation: A solid

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