Description
An inducer of ferroptosis; inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 30 nM), indicating inhibition of the system xc- cystine/glutamate transporter; increases production of lipid ROS in SUDHL6 DLBCL cells in a concentration-dependent manner, as well as reduces GSH levels in these cells (IC50 = 34 nM); inhibits the growth of HT-1080 fibrosarcoma cells (GI50 = 310 nM) as well as HRASG12V-overexpressing BJeLR cells (IC50 = 3 nM); reduces tumor growth in an SUDHL6 mouse xenograft model at 23 and 40 mg/kg
Formal name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-4(3H)-quinazolinone
Synonyms: IKE
Molecular weight: 655.1
CAS: 1801530-11-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
