A prodrug for the active metabolite imidaprilat

Imidapril (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
89396-94-1
Storage:
-20
UN-No:
Non-Hazardous - /

Imidapril is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex.{30612} In clinical trials, imidapril was effective at lowering plasma and tissue angiotensin II levels, resulting in peripheral vasodilation, reduced blood pressure, renoprotective effects in patients with type 1 diabetes, and decreased renal sodium and water retention.{30613,30611}  

 

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Description

A prodrug for the active metabolite imidaprilat, an ACE inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex

Formal name: 3-​[(2S)​-​2-​[[(1S)​-​1-​(ethoxycarbonyl)​-​3-​phenylpropyl]​amino]​-​1-​oxopropyl]​-​1-​methyl-​2-​oxo-4S-​imidazolidinecarboxy​lic acid​, monohydrochloride

Synonyms:  TA-6366

Molecular weight: 441.9

CAS: 89396-94-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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