An IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation; exhibits cardioprotective and anti-cancer properties

IMD 0354 – 1 mg

Brand:
Cayman
CAS:
978-62-1
Storage:
-20
UN-No:
Non-Hazardous - /

IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation.{28402} It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury.{28402} IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis.{28404} It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 µM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.{28403}  

 

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Description

An IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation; exhibits cardioprotective and anti-cancer properties

Formal name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide

Synonyms:  IKK2 Inhibitor V

Molecular weight: 383.7

CAS: 978-62-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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