Description
An imidazole fungicide that inhibits ergosterol biosynthesis; inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7); inhibits S. cerevisiae, but not rat liver microsomal, CYPs (IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM); activates the murine PXR in a concentration-dependent manner in a cell-based reporter assay; increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice at 100 mg/kg; increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the mCAR agonist TCPOBOP
Formal name: 1-[2-(2,4-dichlorophenyl)-2-(2-propen-1-yloxy)ethyl]-1H-imidazole
Synonyms: (±)-Imazalil|Enilconazole
Molecular weight: 297.2
CAS: 35554-44-0
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing||Research Area|Toxicology|Environmental|Agriculture
