A dual inhibitor of ferroptosis and NETosis; inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM

IM-93 – 10 mg

Brand:
Cayman
CAS:
1173657-73-2
Storage:
-20
UN-No:
Non-Hazardous - /

IM-93 is a dual inhibitor of ferroptosis and NETosis.{50250} It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 µM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 µM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide (Item No. 14126) in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 µM.  

 

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SKU: 28794 - 10 mg Category:

Description

A dual inhibitor of ferroptosis and NETosis; inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases PMA-induced NETosis in isolated human peripheral blood neutrophils at 1.6-25 µM; inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 µM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells at 25 µM

Formal name: 3-[[3-(dimethylamino)propyl]amino]-1-(1-methylethyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Synonyms: 

Molecular weight: 368.5

CAS: 1173657-73-2

Purity: ≥98%

Formulation: A crystalline solid

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