A non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM); reduces proliferation and increases differentiation of a ReNCell VM cell line derived from human ventral midbrain

IM-12 – 25 mg

Brand:
Cayman
CAS:
1129669-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM).{28767,28768} It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain.{28768} IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.{28769}  

 

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Description

A non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM); reduces proliferation and increases differentiation of a ReNCell VM cell line derived from human ventral midbrain

Formal name: 3-​[[2-​(4-​fluorophenyl)​ethyl]​amino]​-​1-​methyl-​4-​(2-​methyl-​1H-​indol-​3-​yl)​-1H-​pyrrole-​2,​5-​dione

Synonyms:  GSK3β Inhibitor XIX

Molecular weight: 377.4

CAS: 1129669-05-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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