A DNA alkylating agent from the fungus O. illudens; cytotoxic to HL-60 cells at 6-100 nM

Illudin M – 1 mg

Brand:
Cayman
CAS:
1146-04-9
Storage:
-20
UN-No:
Non-Hazardous - /

Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA.{34634} It is cytotoxic to HL-60 human leukemia cells at 6-100 nM.{28238} Illudin M was used as a base structure for the development of potential anticancer agents with less toxicity and improved efficacy.{28236,34634} It is closely related to illudin S (Item No. 17451), which has been the focus of additional studies.  

 

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Description

A DNA alkylating agent from the fungus O. illudens; cytotoxic to HL-60 cells at 6-100 nM

Formal name: (3’S,6’R)-2′,3′-dihydro-3′,6′-dihydroxy-2′,2′,4′,6′-tetramethyl-spiro[cyclopropane-1,5′-[5H]inden]-7′(6’H)-one

Synonyms:  (-)-Illudin M|DR-15977|NSC 400978|NSC 626370

Molecular weight: 248.3

CAS: 1146-04-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|DNA Alkylating Agents

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