A natural sesquiterpene quinone that reversibly induces vesiculation of Golgi membranes

Ilimaquinone – 100 µg

Brand:
Cayman
CAS:
71678-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.{24002} In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway.{24001,24000} It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 µM).{24002,24003} Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 µM, respectively) and, at 10 µM, activates gene expression through hypoxia-inducible factor-1.{24006,24004}  

 

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Description

A natural sesquiterpene quinone that reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway; inhibits SAH hydrolase (IC50 = 40 µM), DNA polymerase β (IC50 = 45.2 µM,) and Cdc25B (IC50 = 92 µM); at 10 µM, activates gene expression through HIF-1

Formal name: 3-[[(1R,2S,4aS,8aS)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione

Synonyms: 

Molecular weight: 358.5

CAS: 71678-03-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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