A gastric proton pump inhibitor (IC50 = 6 µM for isolated rabbit mucosa); reduces pentagastrin- or histamine-induced gastric acid secretion in anesthetized rats (ED50s = 0.38 and 1.2 mg/kg

Ilaprazole – 5 mg

Brand:
Cayman
CAS:
172152-36-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ilaprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in isolated rabbit gastric mucosa (IC50 = 6 µM).{48937} In vivo, ilaprazole reduces gastric acid secretion induced by pentagastrin (Item No. 28546) or histamine in anesthetized rats (ED50s = 0.38 and 1.2 mg/kg, respectively). It also reduces histamine-induced gastric acid secretion in Heidenhain pouch dogs. Formulations containing ilaprazole have been used in the treatment of peptic ulcers and gastroesophageal reflux disease (GERD).  

 

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SKU: 30120 - 5 mg Category:

Description

A gastric proton pump inhibitor (IC50 = 6 µM for isolated rabbit mucosa); reduces pentagastrin- or histamine-induced gastric acid secretion in anesthetized rats (ED50s = 0.38 and 1.2 mg/kg, respectively); reduces histamine-induced gastric acid secretion in Heidenhain pouch dogs

Formal name: 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole

Synonyms:  (R,S)-Ilaprazole|IY-81149

Molecular weight: 366.4

CAS: 172152-36-2

Purity: ≥98%

Formulation: A solid

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