A specific inhibitor of the MyD88/IL-1RI interaction; inhibits IL-1β-activated phosphorylation of p38 MAP kinase in mouse lymphocytes and thymoma EL4 cells (≥10 μM); has no influence on LPS-mediated TLR4/MyD88 signaling; reduces IL-1β-induced fever (200 mg/kg) and SEB-induced cytokine production and toxicity in mice (2-6 mg dose)

IL-1R Antagonist – 1 mg

Brand:
Cayman
CAS:
566914-00-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

IL-1R antagonist is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI).{39170} In mouse lymphocytes and thymoma EL4 cells, IL-1R antagonist (≥10 μM) inhibits IL-1β-activated phosphorylation of p38 MAP kinase, a process specifically mediated by disruption of IL-1RI/MyD88. However, it has no influence on LPS-mediated TLR4/MyD88 signaling in freshly isolated mouse lymphocytes (100 μM). IL-1R antagonist also attenuates IL-1β-induced fever (200 mg/kg) and Staphylococcal enterotoxin B (SEB)-induced pro-inflammatory cytokine production and toxicity in mice at doses between 2-6 mg.{39170, 39171}  

 

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Description

A specific inhibitor of the MyD88/IL-1RI interaction; inhibits IL-1β-activated phosphorylation of p38 MAP kinase in mouse lymphocytes and thymoma EL4 cells (≥10 μM); has no influence on LPS-mediated TLR4/MyD88 signaling; reduces IL-1β-induced fever (200 mg/kg) and SEB-induced cytokine production and toxicity in mice (2-6 mg dose)

Formal name: N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide

Synonyms: 

Molecular weight: 302.4

CAS: 566914-00-9

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity

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